Figure 1: Schematic representation of the intricate assembly and communication of microsystems including the proteome, lipidome, glycome, and genome in macrosystem. The molecular effectors and affectors and their locations are shown here. The emergence of the metabolome from the microsystems and their interdependence are identified. The application of OMICS-based analyses has been identified at appropriate places. Overall, the cellular system as a whole is controlled or regulated by the structure and function of the microsystems which also dictate the intercellular or transcellular structure and function.