Figure 4: After palmitoylation in the Golgi (1), lipidated proteins enter the secretory pathway (2) and are mainly targeted to the plasma membrane, although some of them can also redistribute to all cellular membranes to reach equilibrium (3). Depalmitoylation catalysed by APT1 takes place all over the cell and the resulting deacylated proteins present are redirected to the Golgi for the next palmitoylation step by local kinetic trapping (4). Myristoylated Lck and Farnesylated N-Ras are depicted as example in this Figure.