Figure 4: Influence of a heparanase inhibitor on TGF-β3-induced EMT of NMuMG cells. NMuMG cells were cultured with 1 ng/ml TGF-β3 together with 10 or 100 μM Heparastatin (SF4) for 48 h. Cell shape after 48 h incubation (A, scale bar: 50 μm) and mRNA expression of E-cadherin (B), and N-cadherin (C) are indicated.