Figure 1: Most relevant lipid modifications in proteins. Isoprenylation of cysteines (either farnesylation or geranylgeranylation) occurs C-terminally, similarly to cholesterylation and the attachment of GPI anchors. Conversely, myristoylation occurs on a N-terminal glycine. The reversible S-acylation is restricted to cysteine residues, usually requiring the presence of a nearby myristoyl or isoprenyl moiety.