Figure 2: The effect of a point mutation on the three dimensional (3D) structures of the human homo-dimeric DPD domain II/III (A) and domain IV (B). A DPD domain II/III sequence of pig (top left), human (top middle) and its mutant K259E (top right) (A) and the DPD domain IV sequence of pig (bottom right), human (bottom middle), and its mutant exon 14 skipping (In G1A, bottom right) (B) were subjected to the SWISS-MODEL to predict their quaternary structures. Exon 14 skipping, but not K259E mutation significantly changes core functional sites of the DPD domain IV 3D structure.