Figure 3: The effect of a point mutation on the three dimensional (3D) structures of the homo-dimeric human DPD domain V. A DPD domain V sequence of pig (left), human (second left) and its point mutants, D949V (second right) and C953S (right) was subjected to the SWISS-MODEL to predict their quaternary structures. Both mutants alter the 3D structure of DPD domain V to interfere Fe-S clustering.