Note: Rats were administered a single oral gavage dose of APAP and serum was collected 24 h after dosing. Histopathology lesions were scored on a 5 point scale (0 = normal, 1 = minimal, 2 = mild, 3 = moderate, 4 = marked). *Statistically significant increase compared to the low dose APAP (100 mg/kg) group (p ≤ 0.05). Histopathology scores were not statistically analyzed. |
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Table 1: Inter-individual variability in traditional biochemical and histopathological indices of hepatocellular injury 24h after a single oral dose of APAP. |