Table 1

	Animal #	Activity, (IU/L)		Histopathology
		ALT	AST	Centrilobular Glycogen Depletion	Centrilobular Necrosis
Control	1	69	114	0	0
	2	65	90	0	0
	3	71	105	0	0
	4	65	83	0	0
	MEAN +/- SD	67.5 ± 3.0	98.0 ± 14.1	0	0

100 mg/kg APAP	5	47	91	0	0
	6	55	122	0	0
	7	59	120	0	0
	8	59	76	0	0
	MEAN +/- SD	55.0 ± 5.7	102.2 ± 22.5	0	0

1250 mg/kg APAP	9	59	127	1	0
	10	1523	7580	4	3
	11	69	131	1	0
	12	71	108	2	1
	13	65	117	2	2
	14	68	103	1	0
	15	1364	12880	4	3
	MEAN +/- SD	459.9 ± 673.5*	3006.6 ± 5166.3	2.1 ± 1.3	1.3 ± 1.4

Note: Rats were administered a single oral gavage dose of APAP and serum was collected 24 h after dosing. Histopathology lesions were scored on a 5 point scale (0 = normal, 1 = minimal, 2 = mild, 3 = moderate, 4 = marked).
*Statistically significant increase compared to the low dose APAP (100 mg/kg) group (p ≤ 0.05). Histopathology scores were not statistically analyzed.

Table 1: Inter-individual variability in traditional biochemical and histopathological indices of hepatocellular injury 24h after a single oral dose of APAP.