miRNA ID |
Control |
100 mg/kg APAP |
1250 mg/kg APAP |
rno-miR-376a |
0.2 + 0.1 |
1.1 + 0.5 |
6.0 + 2.1 |
rno-miR-130a |
0.5 + 0.1 |
3.1 + 1.6 |
8.5 + 2.5 |
rno-miR-674-3p |
0.5 + 0.2 |
2.6 + 0.5 |
7.8 + 2.2 |
rno-miR-463 |
0.6 + 0.3 |
1.5 + 0.6 |
4.0 + 1.0 |
rno-miR-185 |
0.6 + 0.3 |
0.7 + 0.3# |
6.7 + 1.7 |
rno-miR-17-5p |
0.6 + 0.2 |
4.2 + 1.7 |
11.5 + 3.4 |
rno-miR-485 |
0.6 + 0.5 |
0.5 + 0.1# |
3.7 + 0.5 |
rno-miR-152 |
0.7 + 0.4 |
1.0 + 0.5# |
4.9 + 1.1 |
rno-miR-425 |
0.8 + 0.4 |
1.3 + 0.5 |
4.4 + 0.9 |
rno-miR-449a |
0.8 + 0.4 |
3.5 + 1.9 |
13.0 + 5.2 |
rno-miR-181c |
0.8 + 0.4 |
1.2 + 0.6# |
6.0 + 1.1 |
rno-miR-327 |
0.8 + 0.4 |
0.7 + 0.2# |
3.8 + 0.9 |
rno-miR-151* |
0.9 + 0.4 |
1.7 + 0.6 |
13.1 + 5.1 |
rno-miR-380 |
0.9 + 0.1 |
1.4 + 0.8 |
3.5 + 0.7 |
rno-miR-664 |
0.9 + 0.6 |
2.7 + 0.6 |
7.2 + 1.4 |
rno-miR-343 |
1.0 + 0.7 |
2.5 + 1.2 |
7.6 + 1.7 |
rno-miR-379 |
1.0 + 0.2 |
3.0 + 1.2 |
3.9 + 1.0 |
rno-miR-135a* |
1.1 + 0.5 |
2.7 + 0.6 |
5.2 + 0.7 |
rno-miR-124* |
1.1 + 0.4 |
3.7 + 1.2 |
7.4 + 2.0 |
rno-miR-344-5p |
1.2 + 0.7 |
2.3 + 1.0 |
7.9 + 2.6 |
rno-miR-423 |
1.2 + 0.4 |
1.4 + 0.4# |
10.2 + 3.4 |
rno-miR-291a-5p |
1.3 + 0.5 |
6.6 + 1.7 |
20.4 + 5.0 |
rno-miR-30d* |
1.4 + 0.6 |
4.3 + 1.1 |
10.3 + 3.2 |
rno-miR-342-3p |
1.5 + 0.6 |
4.9 + 1.3 |
25.7 + 10.1 |
rno-miR-542-5p |
1.6 + 1.0 |
5.4 + 2.0 |
10.7 + 2.0 |
rno-miR-330* |
2.0 + 0.8 |
2.6 + 0.4# |
18.3 + 6.4 |
rno-miR-222 |
2.0 + 0.7 |
10.1 + 5.3 |
14.5 + 4.0 |
rno-miR-134 |
2.1 + 0.8 |
5.0 + 1.9 |
20.2 + 4.9 |
rno-miR-328 |
2.1 + 0.7 |
2.9 + 1.0# |
18.6 + 4.0 |
rno-miR-433 |
2.3 + 0.8 |
4.4 + 2.1 |
38.6 + 9.9 |
rno-miR-221 |
2.5 + 0.5 |
4.5 + 1.2 |
8.8 + 2.1 |
rno-miR-203 |
2.6 + 1.0 |
12.9 + 3.4 |
32.8 + 12.8 |
rno-miR-434 |
2.6 + 0.9 |
4.9 + 1.3 |
18.9 + 5.3 |
rno-miR-298 |
2.7 + 1.3 |
4.3 + 1.2 |
15.4 + 2.8 |
rno-miR-20b-3p |
3.2 + 1.4 |
5.2 + 1.1 |
27.6 + 10.6 |
rno-miR-99b* |
4.1 + 2.2 |
10.8 + 5.1 |
41.9 + 10.4 |
rno-miR-34c* |
5.2 + 0.8 |
7.2 + 1.4# |
44.5 + 15.8 |
rno-miR-484 |
5.3 + 1.2 |
6.1 + 0.7# |
31.7 + 11.0 |
rno-miR-760-3p |
5.5 + 1.6 |
16.1 + 2.9 |
24.8 + 3.0 |
rno-miR-191 |
5.6 + 0.8 |
7.9 + 1.7# |
36.4 + 8.8 |
rno-miR-489 |
13.8 + 2.5 |
40.7 + 9.1 |
54.4 + 10.9 |
rno-let-7b* |
14.7 + 4.3 |
23.8 + 5.5 |
74.0 + 20.4 |
rno-miR-296 |
16.7 + 5.7 |
37.1 + 7.6 |
93.4 + 22.6 |
rno-miR-92b |
114.8 + 43.5 |
213.1 + 51.8 |
575.2 + 135.3 |
Note. The relative miRNA levels were calculated by 2-ΔCt, normalized to three
housekeeping miRNAs (miR-193, miR-323*, and miR-675), and presented as
mean + SEM, p < 0.01. #: Fold change less than 1.5 compared between APAP low
dose and the control. |
