Function

Gene Title

Public ID

Fold

change

 

 

 

 

Palmitate

Palmitate + pioglitazone

Palmitate + exenatide

Regulation of gene expression, epigenetic

Fibroblast growth factor receptor 2 (FGFR2)

NM_022975

1.7

3.4

2.4

 

Calreticulin (CALR)

AA910371

1.6

 

 

 

Aldolase B, fructose-bisphosphate (ALDOB)

BC005314

 

6.5

5.4

 

Tropomyosin 3, 4 (TPM3, TPM4)

AF362887

 

4.9

7.4

 

Insulinoma-associated 1 (INSM1)

BF108585

 

2.5

2.1

 

YY1 transcription factor (YY1)

AA748649

 

2.5

 

 

Mitogen-activated protein kinase kinase 3 (MAP2K3)

AA780381

 

2.4

1.7

 

Acetyl-Coenzyme A carboxylase beta (ACACB)

AI970898

 

1.9

1.8

 

GLIS family zinc finger 3 (GLIS3)

AW025602

 

1.7

 

 

Caveolin 2 (CAV2)

AA150110

 

1.6

1.7

 

Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A)

AA769818

 

1.6

 

 

Aryl hydrocarbon receptor nuclear translocator (ARNT)

AL137290

 

 

2.0

 

Sp1 transcription factor (SP1)

AU121035

 

 

1.9

 

Cysteine-rich, angiogenic inducer, 61 (CYR61)

NM_001554

 

 

1.8

 

ATPase, Cu++ transporting, alpha polypeptide (ATP7A)

NM_000052

 

 

1.6

 

Transcription factor 4 (TCF4)

BF592782

 

 

1.6

Metabolism

Voltage-dependent anion channel 3 (VDAC3)

U90943

 

2.3

2.4

 

Ras homolog gene family, member Q (RHOQ)

BF978689

 

2.0

2.3

 

Solute carrier family 22, member 5 (SLC22A5)

NM_003060

 

1.8

1.7

 

ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1)

NM_004996

 

1.6

 

 

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e (ATP6V0E)

NM_003945

 

5.1

4.2

 

Transferrin receptor (TFRC)

N76327

 

 

1.6

 

Transient receptor potential cation channel, subfamily C, member 1(TRPC1)

U31110

 

 

1.6

 

Alcohol dehydrogenase IB (class I), beta polypeptide (ADH1B)

M21692

 

 

1.5

 

Nuclear factor related to kappaB binding protein (NFRKB)

AI869532

 

 

1.5

 

Syntaxin 7 (STX7)

NM_003569

 

 

1.5

Apoptosis

Lectin, galactoside-binding, soluble, 1 (galectin 1)( LGALS1)

NM_002305

1.9

 

 

 

Caspase recruitment domain family, member 10 (CARD10)

AY028896

1.6

 

 

 

Serine/threonine kinase 4 (STK4)

BE222274

1.5

 

 

 

Pleckstrin homology-like domain, family A, member 1 (PHLDA1)

AI795908

1.7

 

 

 

Apolipoprotein E (APOE)

N33009

 

2.5

1.5

 

Secreted phosphoprotein 1 (SPP1)

AB019562

 

4.8

3.0

 

Tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A)

W65310

 

2.5

 

 

Ras homolog gene family, member B (RHOB)

AI263909

 

2.4

2.1

 

Neuronal thread protein AD7c-NTP (AD7C-NTP)

AF010144

 

1.6

1.6

 

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D)

NM_006378

 

1.5

 

 

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) (DFFB)

NM_004402

 

1.5

 

 

Protein phosphatase 1, regulatory (inhibitor) subunit 13B (PPP1R13B)

AK023188

 

 

1.8

 

Programmed cell death 6 (PDCD6)

AI692169

 

 

1.6

Signal transduction

Growth differentiation factor 15 (GDF15)

BC000529

1.9

7.4

7.5

 

Striatin, calmodulin binding protein 4 (STRN4)

NM_013403

1.6

 

 

 

Protein tyrosine kinase 9 (PTK9)

N25562

 

3.1

1.7

 

Chemokine (C-X-C motif) ligand 2 (CXCL2)

M57731

 

2.3

2.0

Table 3: Transcripts down-regulated by palmitate, with or without pioglitazone or exenatide, in non-diabetic human islets.