SNP

Group

Genotype frequencies

Allele frequencies

p-value
(OR; 95% CI)

BCRP C421A

 

CC

CA

AA

C

A

 

Controls

15 ( 0.88)

2 (0.12)

0 (0.00)

0.94

0.06

 

UC

23 (0.68)

10 (0.29)

1 (0.03)

0.82

0.18

0.18
(3.51; 0.63-37.03)

CD

31 (0.82)

7 (0.18)

0 (0.00)

0.91

0.09

0.71
(1.68; 0.27 – 18.47)

IBD

54 (0.75)

17 (0.24)

1 (0.01)

0.91

0.09

0.35
(2.48; 0.50 – 24.43)

MDR1 C3435T

 

CC

CT

TT

C

T

 

Controls

4 (0.24)

9 (0.53)

4 (0.24)

0.50

0.50

 

UC

5 (0.15)

21 (0.62)

8 (0.24)

0.46

0.54

0.46
(1.76; 0.30 – 9.78)

CD

7 (0.17)

23 (0.61)

8 (0.21)

0.49

0.51

0.73
(1.36; 0.25 – 6.50)

IBD

12 (0.17)

44 (0.61)

16 (0.22)

0.49

0.51

0.50
(1.53; 0.31 – 6.20)

MDR1 G2677T

 

GG

GT

TT

G

T

 

Controls

12 (0.71)

5 (0.29)

0 (0.00)

0.85

0.15

 

UC

29 (0.93)

5 (0.15)

0 (0.00)

0.93

0.07

0.27
(0.42; 0.08 – 2.20)

CD

30 (0.79)

7 (0.18)

1 (0.03)

0.88

0.12

0.52
(0.65; 0.15 – 3.04)

IBD

59 (0.82)

12 (0.17)

1 (0.01)

0.88

0.12

0.33
(0.53; 0.14 – 2.27)
Table 2: Genotype and allele frequencies of BCRP C421A, MDR1 C3435T, and MDR1 G2677T in UC (n=34), CD (n=38), IBD (n=72), and healthy controls (n=17). All groups are in Hardy-Weinberg equilibrium, OR = odds ratio; CI = confidence interval