Biomarker

Omics

Analytical Method

Sample Source

Marker type

Regulation (ratio)

Ref

Lysozyme

Proteomics

HPLC-ESI/MS

Tear (Rabbit)

Corneal wounding

Up (8)

[14]

Neutrophil defensins NP-1 and NP-2

Proteomic

SELDI-TOF-MS Protein Chip

Tear (Rabbit)

Corneal wounding

Up (6.4–10.2)

[41]

A-defensins (HNP-1, HNP-2, and HNP-3)

Proteomic

SELDI-TOF-MS Protein Chip

Tear (Human)

Ocular surface surgery

Up (>10)

[42]
Ratio: (diseased eye)/(normal eye) HPLC-ESI/MS: high-performance liquid chromatography-electrospray ionization/mass spectrometry, SELDI-TOF: surface-enhanced laser desorption ionization-time of flight
Table 2: Tear- and meibum-associated potential protein biomarkers tentatively identified for corneal wounding in animal models and human subpopulations [28].