Biomarker

Omics

Analytical Method

Sample Source

Marker type

Regulation

Ref.

Protein S100-A8
Protein S100-A9
Protein S100-A4
GTP-bunding protein 2
L-lactate dehydrogenase A like 6B
Fatty acid-binding protein
Keratin type I cytoskeletal 10
Glutathione S-transferase P
Peroxiredoxin-1
Peroxiredoxin-5
Cullin-4B + glyceraldehyde 3-phosphate dehydrogenase

Proteomic

2-D SDS-PAGE
MALDI-TOF/MS

Tear (Human)

Conjunctivochalasis

Up (2.44)
Up (1.71)
Up (2.82)
Up (1.95)
Up (2.32)

 

Up (2.01)

Up (1.81)

Up (2.27)

Up (1.79)
Up (1.92)
Up (1.96)

[56]

IL-1β
IL-6
Pro-MMP-9

Proteomic

ELISA

Tear (Human)

Conjunctivochalasis

Up (4.2)
Up (6.3)
Up (5.3)

[52]
2-D-SDS-PAGE: two-dimensional-sodium dodecyl sulfate polyacrylamide gel electrophoresis, MALDI-TOF/MS: matrix assisted laser desorption ionization-time of flight/ mass spectrometry, ELISA: enzyme-linked immunosorbent assay
Table 6: Tear- and meibum-associated potential protein and lipid biomarkers tentatively identified for conjunctivochalasis in animal models.