Table 1

miRNA	Expression				Confirmed targets	Associated with		Reference
	NSCLC		SCLC			Diagnosis	Survival¹
	Tumors	Lines	Tumors	Lines		Diagnosis	Survival¹
let-7	Dn	Dn	UC		HMGA2, RAS, MYC, E2Fs, CDKs	SCC	NSCLC	[24, 25, 54, 65, 77, 78, 80, 81, 105]
miR-7	Up			Up	ETS2, EGFR, Raf1			[24, 54]
miR-9	Dn/Up			Up	TGFBI, TRIM2, SIRT1, BTBD3	SCLC		[24, 25, 54, 106]
miR-15	Up	NC	Up	Dn/Up	Bcl-2, CCND1, CCNE		NSCLC	[10, 54, 77-79]
miR-16	Dn	NC		Dn/Up	Bcl-2, CCND1, CCNE		NSCLC	[10, 24, 54, 65, 79]
miR-17-3p,5p	Up		Up	Up	p21, E2F, Bim, CCND1, PTEN, Rb	NSCLC		[25, 40, 54, 77, 78, 107]
miR-17-92 cluster	Up	Up	Up	Up	p21, E2F, CCND1, PTEN, Rb, HIF-1α	SCLC	SCLC	[40, 54]
miR-20	Up			Up	p21, E2F, Bim, Cyclin D1, PTEN, Rb	NSCLC		[40, 54, 77, 78]
miR-21	Up	Up	UC	Dn	Apaf-1, PTEN, PDCD4, Faslg, Spry1-2, Btg2	NSCLC ; ADC	NSCLC	[10, 23-25, 43, 44, 54, 64, 65, 77-79, 95, 107, 108]
miR-22		UC		Dn	PTEN, ESR1, TIAM1			[10, 109, 110]
miR-23a,b	Up	NC		Dn	Has2, LaminB1, Brn-3b		NSCLC	[10, 54, 79]
miR-24	Up	NC		Dn	E2F2, Myc, Net1A		NSCLC	[10, 25, 79]
miR-25	Up		Up	Up	Bim, TRAIL	NSCLC	NSCLC	[54, 60, 78, 111]
miR-27b	Dn		UC	UC	ST14, PPARα		NSCLC	[25, 54, 79]
miR-29a,b,c	Dn	NC	Dn	Dn	DNMT3 (A&B)			[10, 23, 25, 54]
miR-30	Dn			Dn	p53, B-Myb, CTGF			[22-25, 54, 65]
miR-30c, d	Dn	Up		Up	Serpine1		NSCLC	[10, 65, 79, 82, 112]
miR-31	Up	Dn		Dn	LATS2, PPP2R2A	ADC		[10, 23, 46, 64, 65]
miR-32	Dn			Dn	Bim			[25, 54]
miR-33	Dn			Dn	ABCA1, p53			[25, 54, 113, 114]
miR-34a	Dn/Up			Dn	DLL1, CDK4, Myc, CCND1		NSCLC	[23, 54, 78, 115, 116]
miR-92		UC		Up	Bim			[10, 54, 117]
miR-93		UC		Up	p21, FUS1	SCLC		[10, 54, 111, 118]
miR-95	Dn		Up	Up	SNX1	SCLC		[25, 54, 119]
miR-96	Up	Up	Up	Up	GPC3, FOXO1		NSCLC	[10, 54, 120]
miR-98		UC	Up	Up	FUS1	SCLC		[10, 54, 93, 118]
miR-99	Dn			Dn	SMARCA5, SMARCD1, mTOR			[10, 23, 65, 121]
miR-100	Dn			Dn	ATM, PLK1, MTOR, RPTOR, IGF1R, Gli1		SCC	[23, 54, 77, 78]
miR-101	Dn	Up		Up	Mcl-1			[10, 22-25, 47-49]
miR-106a	Up		Up	Up	E2F1	ADC	OS-NSCLC	[10, 54, 77, 78, 111]
miR-106b		Up		Up	p21, E2F, Bim, Cyclin D1, PTEN, Rb			[10, 54, 77, 78, 111]
miR-125	Dn		Dn	Dn	Smo, invasion and migration factors	NSCLC		[23, 25, 54, 65, 77, 122]
miR-126	Dn		Dn	Dn	Spred-1	SCC, ADC	SCC	[22-25, 64, 65, 77, 78]
miR-126*	Dn				ERBB2IP	NSCLC		[23-25, 95]
miR-128	Dn			Up	EGFR	SCLC	EGFR-TKi2	[45, 54]
miR-130a	Dn			Dn	MET		NSCLC	[23, 24, 54, 65, 79]
miR-130b	Up		Up	Up	CSF-1, TP53INP1, RUNX3	SCC		[54, 64, 65]
miR-133b	Dn			Dn	Mcl-1, BCLw			[24, 54]
miR-139	Dn				ROCK2, FOXO1, CXCR4	SCC		[24, 64, 65, 123-125]
miR-140	Dn				Sp1, BMP2	ADC		[25, 64]
miR-142-3p,5p		Up		Dn/Up	ADAM9, GRα, PKA			[10, 54]
miR-143	Dn			Dn	ERK5, KRAS, Bcl-2, DNMT3A, ELK1	ADC		[23-25, 54, 64];
miR-145	Dn			Dn	c-MYC, CDK4, eIF4E4	NSCLC; ADC		[23-25, 54, 64]
miR-146b	Up			Dn	MMP16, TRAF6, IRAK1,	ADC	SCC	[25, 54, 77, 78, 107]
miR-149	Up	Up		Up	E-cadherin	SCC		[10, 55, 65]
miR-150	Up/Dn		Dn	Dn	MUC4, P2RX7	ADC		[25, 54, 64]
miR-155	Up			Dn	TAB2, FADD, RIP-1, IKKϵ, ET-1	ADC	NSCLC	[25, 54, 61, 77, 78, 107]
miR-181a,b	Dn		Dn	Dn	Mcl-1, Bcl-2			[23, 54, 65]
miR-181c	Dn	NC		Up	TGFBI, TRIM2, SIRT1, BTBD3			[10, 65, 106]
miR-182	Up		Up	Up	FOXO1	NSCLC, ADC	NSCLC	[24, 54, 61, 64, 65, 77, 78, 80, 95, 120]
miR-183	Up		Up	Up	FOXO3, FOXO1, EGR1, PTEN	NSCLC	NSCLC	[24, 54, 65, 77, 95, 120]
miR-185	Dn	Dn		Dn	c-Myc, DNMT1, SMG6, CDK6, AKT1			[54, 126]
miR-191	Up			Dn	CDK6, TIMP3, NDST1	ADC	SCC	[25, 54, 77, 78, 107]
miR-192	Up				ERCC3, ERCC4, Rb1			[25, 107]
miR-195	Dn	NC		Dn/Up	CCNE, BCLw			[10, 24, 54, 65]
miR-197	Up	Up		Up	FUS1			[10, 25, 61]
miR-199	Dn	Dn	Dn	Dn	HES, ET-1, HIF-1α			[10, 21, 25, 54]
miR-200a,b	Dn/Up		Up	Up	C-ets-1, Zeb1, ECM proteins, p38α	ADC	NSCLC	[54, 64, 79, 127]
miR-200c	Up	Dn	Up	Up	C-ets-1, Zeb1, ECM proteins	SCC	NSCLC	[54, 65, 77, 128]
miR-203	Up		.		DeltaNp63, Smo	NSCLC, ADC		[25, 77, 107]
miR-205	Up	Dn		Dn	E2F1, Zeb1, Sip1	SCC; ADC		[10, 25, 65, 74, 75, 78, 93, 107]
miR-210	Up		Up	Up	HOXA1, FGFRL1, HOXA9, NDUFA4, EFNA3	NSCLC , SCC, ADC		[24, 25, 54, 57, 64, 65, 77, 95, 107, 108, 129]
miR-214	Up		Dn	Dn	EZH2, Brn-3b	ADC		[25, 54, 107]
miR-218	Dn				RICTOR	ADC		[24, 25, 64]
miR-221	Up/UC			Dn	p27, PTEN, TIMP3		NSCLC	[10, 50, 80]
miR-222	Up/UC			Dn	p27, PTEN, TIMP3			[10, 50, 54]
miR-223	Dn/Up		Dn	Dn	LMO2-L/-S, CEBP-β	NSCLC		[54, 60, 65]
miR-224	Dn/Up			Dn	DIO1			[77]
miR-324-5p	Up	Up	Up	Up/Dn	Smo, Gli1	SCC		[10, 54, 65, 130]
miR-326		Up		Up	MRP-1/ABCC1, Ets-1			[10, 131, 132]
miR-335	Dn		Up	Up	SOD2, Txnrd2, BCLw, SP1, ERα, IGF1R			[24, 54, 133-135]
miR-338	Dn	Up		Up/Dn	Runx2, Smo			[10, 24, 54, 130, 136]
miR-375	Up	Dn	Up	Up	IGF1R, SP1, LDHB, YAP1	ADC	SCLC	[54, 64, 137-140]
miR-423	Up				p21	SCC		[24, 65, 141]
miR-429	Dn			Up	ALDH1L2, PSAT1, ZEB1	SCC		[54, 65, 142]
miR-451	Dn			Dn	RAB14, apoptosis			[23, 24, 54]
miR-453	Dn				ESR1		SCC	[77, 78, 82]
miR-486	Dn				CD40	ADC	NSCLC	[64, 65, 108]
miR-494	Dn			Up	Nucleolin, Bmal1		SCC	[54, 77, 78, 143, 144]
miR-497	Dn			Dn	BCL2, CCND2			[24, 54, 145]{Xing, 2010 #85
miR-504	Up				p53, DRD1			[23, 146, 147]
miR-511	Up			Dn	TLR4, CD80		SCC	[54, 77, 78, 148]
miR-512				Dn	c-FLIP, Mcl-1			[54, 149, 150]

¹Expression trend can be either positively or negatively correlated to overall survival
²Associated with drug response and not to overall survival
Abbreviations: Lines = cell lines, SCC = lung squamous cell carcinoma, ADC = lung adenocarcinoma, Up = increased expression, Dn = decreased expression, UC = no
change

Table 1: Frequently deregulated miRNAs in lung cancer.