Figure 1: Cholesterol-enriched diet induced the accumulation of A β-like plaques in rabbit brain. A. ELISA assay showed that the 2% cholesterol-enriched diet significantly increased both Aβ42 and Aβ40 levels. Values from control (n = 6) and 12 week cholesterol-fed (n = 6) rabbits were expressed as mean ± standard deviation, *p<0.05, ***p<0.01. B. While Thioflavin staining revealed no immunoreactivity to Aβ42 in control rabbits, Aβ42-like plaques was present in hippocampus of 12 week cholesterol-fed rabbits (arrows) as observed under fluorescence microscope. Scale bar = 50 μm.