| pSS patients (n= 15) |
Controls (n= 15) |
| Metabolite |
Concentration (µM) |
Concentration (µM) |
Significance
P value (a) |
| Mean ± S.D |
Range |
P value (a) |
Range |
| Acetate |
1482.7 ± 952.6 |
202.7-3676.6 |
1503.0 ± 715.2 |
670.6-3035.2 |
0.948 |
| Alanine |
23.7 ± 13.2 |
7.0-55.6 |
11.4 ± 7.3 |
2.5-27.6 |
0.004** |
| Butanol |
14.1 ± 12.1 |
1.5-45.1 |
8.6 ± 5.8 |
0.8-20.7 |
0.126 |
| Butyrate |
34.7 ± 29.0 |
7.2-107.8 |
16.4 ± 10.9 |
2.5-34.9 |
0.034* |
| Choline |
11.4 ± 5.3 |
4.5-24.7 |
4.1 ± 2.0 |
1.0-7.1 |
<0.001*** |
| Citrate |
18.3 ± 7.9 |
7.2-34.4 |
18.3 ± 13.8 |
3.4-46.5 |
0.996 |
| Ethanol |
25.4 ± 12.8 |
7.2-57.7 |
26.3 ± 59.6 |
7.9-241.3 |
0.956 |
| Formate |
152.0 ± 195 |
6.3-660.8 |
80.1 ± 63.3 |
3.3-220.5 |
0.192 |
| Fucose |
46.5 ± 35.9 |
3.7-113.6 |
66.3 ± 40.3 |
20.2-150.5 |
0.167 |
| Glycine |
150.9 ± 120.5 |
16.0-387.7 |
51.5 ± 35.4 |
8.7-152.3 |
0.007** |
| Histidine |
30.3 ± 13.9 |
8.7-53.8 |
- |
- |
- |
| Isopropanol |
1.84 ± 0.8 |
0.2-3.7 |
- |
- |
- |
| Lactate |
265.6 ± 140.4 |
25.4-509.7 |
198.3 ± 174.5 |
14.1-649.0 |
0.255 |
| Methanol |
28.5 ± 17.5 |
9.7-65.6 |
27.7 ± 9.2 |
8.3-43.9 |
0.878 |
| Methylamine |
2.1 ± 1.7 |
0.5-5.7 |
2.0 ± 0.9 |
1.1-3.8 |
0.818 |
| Phenylalanine |
14.3 ± 8.4 |
2.6-28.6 |
8.5 ± 3.6 |
2.6-16.8 |
0.026* |
| Proline |
133.5 ± 114.5 |
9.1-362.9 |
59.1 ± 44.1 |
17.8-160.5 |
0.032* |
| Propionate |
284.3 ± 205.7 |
49.8-722.1 |
235.7 ± 156.2 |
69.0-621.9 |
0.472 |
| Pyruvic acid |
17.6 ± 11.2 |
0.9-37.5 |
10.4 ± 7.8 |
0.0-24.3 |
0.050 |
| Succinate |
33.8 ± 32.1 |
6.7-131.8 |
28.2 ± 15.7 |
5.3-49.5 |
0.549 |
| Taurine |
110.5 ± 49.6 |
18.6-213.0 |
48.3 ± 29.0 |
12.5-111.5 |
<0.001*** |
| Trimethylamine |
1.4 ± 1.4 |
0.1-4.9 |
- |
- |
- |
| Tyrosine |
26.7 ± 18.5 |
5.1-75.4 |
19.6 ± 11.4 |
6.4-50.5 |
0.215 |
| 1,2-propanediol |
40.1 ± 71.4 |
9.2-290.0 |
27.3 ± 14.2 |
9.8-59.0 |
0.500 |
(a)Student’s t-test; p< 0.001***; p<0.01**; p<0.05* |
