Figure 3: Schematic diagram of potentially disturbed metabolic pathway networks associated with the significantly altered metabolites during melanoma development based on the findings from this work and the diverse metabolic fates depicted in the Small Molecule Pathway Database (SMPDB) ( and literatures. Solid line indicates one-step process, while dash line indicates multi-steps process. Metabolites colored green are not detected. Metabolic pathways under the numbered shadow squares are parts of metabolism networks of particular metabolites: 1 purine metabolism, 2 glycine and serine metabolism, 3 pyrimidine metabolism, 4 pyruvate metabolism, 5 glutamate metabolism, 6 tryptophan metabolism, 7 threonine degradation. Other significantly affected metabolites pathways are valine, leucine, isoleucine degradation, lipids metabolism, methionine metabolism and TCA cycle