(a) The list of unique metabolites of serum.
name kegg ap bFN
  C00065 0.019 0.42
(9Z, 12Z)-Octadecadienoic acid C01595 0.028 0.45
D-Lactic acid C00256 0.040 0.48
2-Oxopropanoate C00022 0.040 0.48
Succinic acid C00042 0.040 0.48
Ascorbic acid C00072 0.040 1.87
(b) The list of unique metabolites of liver.
name kegg ap bFN
D-Glucose C00031 0.007 2.33
2-Oxobutanedioic acid C00036 0.042 0.44
L-Alanine C00041 0.017 0.36
aspartic acid C00049 0.027 0.40
L-Ornithine C00077 0.042 0.44
L-Tryptophan C00078 0.007 0.29
Sucrose C00089 0.011 2.22
Myo-Inositol C00137 0.017 2.11
D-Mannose C00159 0.017 2.11
Cobalt C00175 0.027 0.40
L-Valine C00183 0.017 0.36
Cellobiose C00185 0.007 2.33
Maltose C00208 0.027 2.00
Arachidonic acid C00219 0.017 0.36
Pyrimidine C00396 0.011 0.33
Glucitol C00794 0.007 2.33
5-Oxoproline C01879 0.042 0.44
D-Lactose C01970 0.006 2.33
Phosphoramidate C02306 0.017 2.11
3-Methyloxindole C02366 0.007 2.33
Acetyl-L-Lysine C02727 0.027 0.40
Gulose C06465 0.027 2.00
Oxycodone C08018 0.017 0.36
Purine C15587 0.017 0.36
(c) The information of changed pathways in serum.
dclass Label cp-value
Amino acid metabolism Cysteine and methionine metabolism 3.73E-02
Amino acid metabolism Glycine, serine and threonine metabolism 2.92E-02
Amino acid metabolism Alanine, aspartate and glutamate metabolism 2.66E-04
Carbohydrate metabolism Glycolysis / Gluconeogenesis 1.22E-02
Carbohydrate metabolism Fructose and mannose metabolism 2.81E-02
Carbohydrate metabolism Starch and sucrose metabolism 1.27E-04
Carbohydrate metabolism Galactose metabolism 1.82E-06
Global and overview maps Metabolic pathways 1.44E-02
Membrane transport ABC transporters 4.67E-12
Metabolism of cofactors and vitamins Pantothenate and CoA biosynthesis 9.35E-03
Metabolism of other amino acids Glutathione metabolism 1.81E-02
Translation Aminoacyl-tRNA biosynthesis 6.15E-04
(d) The information of changed pathways in liver.
dclass Label cp-value
Amino acid metabolism Phenylalanine metabolism 3.17E-03
Amino acid metabolism Alanine, aspartate and glutamate metabolism 8.63E-04
Amino acid metabolism Tyrosine metabolism 8.51E-03
Amino acid metabolism Cysteine and methionine metabolism 4.68E-03
Amino acid metabolism Glycine, serine and threonine metabolism 3.60E-03
Carbohydrate metabolism Citrate cycle (TCA cycle) 5.96E-04
Carbohydrate metabolism Butanoate metabolism 2.40E-03
Carbohydrate metabolism Glyoxylate and dicarboxylate metabolism 2.91E-03
Carbohydrate metabolism Pyruvate metabolism 1.54E-03
Carbohydrate metabolism Ascorbate and aldarate metabolism 3.31E-03
aP value was obtained from Mann-Whitney test (model group compared to control group).
bFN is fold change of mean ranks calculated by the Mann-Whitney test(model group compared to control group). “<1” means up-regulated, “>1” means down-regulated.
cP-val is obtained from analysis of MBRole.
dclass were categorized by KEGG.
Table 5: The different metabolites and pathways of FLD.