| (a) The list of unique metabolites of serum. |
| name |
kegg |
ap |
bFN |
| |
C00065 |
0.019 |
0.42 |
| (9Z, 12Z)-Octadecadienoic acid |
C01595 |
0.028 |
0.45 |
| D-Lactic acid |
C00256 |
0.040 |
0.48 |
| 2-Oxopropanoate |
C00022 |
0.040 |
0.48 |
| Succinic acid |
C00042 |
0.040 |
0.48 |
| Ascorbic acid |
C00072 |
0.040 |
1.87 |
|
| (b) The list of unique metabolites of liver. |
| name |
kegg |
ap |
bFN |
| D-Glucose |
C00031 |
0.007 |
2.33 |
| 2-Oxobutanedioic acid |
C00036 |
0.042 |
0.44 |
| L-Alanine |
C00041 |
0.017 |
0.36 |
| aspartic acid |
C00049 |
0.027 |
0.40 |
| L-Ornithine |
C00077 |
0.042 |
0.44 |
| L-Tryptophan |
C00078 |
0.007 |
0.29 |
| Sucrose |
C00089 |
0.011 |
2.22 |
| Myo-Inositol |
C00137 |
0.017 |
2.11 |
| D-Mannose |
C00159 |
0.017 |
2.11 |
| Cobalt |
C00175 |
0.027 |
0.40 |
| L-Valine |
C00183 |
0.017 |
0.36 |
| Cellobiose |
C00185 |
0.007 |
2.33 |
| Maltose |
C00208 |
0.027 |
2.00 |
| Arachidonic acid |
C00219 |
0.017 |
0.36 |
| Pyrimidine |
C00396 |
0.011 |
0.33 |
| Glucitol |
C00794 |
0.007 |
2.33 |
| 5-Oxoproline |
C01879 |
0.042 |
0.44 |
| D-Lactose |
C01970 |
0.006 |
2.33 |
| Phosphoramidate |
C02306 |
0.017 |
2.11 |
| 3-Methyloxindole |
C02366 |
0.007 |
2.33 |
| Acetyl-L-Lysine |
C02727 |
0.027 |
0.40 |
| Gulose |
C06465 |
0.027 |
2.00 |
| Oxycodone |
C08018 |
0.017 |
0.36 |
| Purine |
C15587 |
0.017 |
0.36 |
|
| (c) The information of changed pathways in serum. |
| dclass |
Label |
cp-value |
| Amino acid metabolism |
Cysteine and methionine metabolism |
3.73E-02 |
| Amino acid metabolism |
Glycine, serine and threonine metabolism |
2.92E-02 |
| Amino acid metabolism |
Alanine, aspartate and glutamate metabolism |
2.66E-04 |
| Carbohydrate metabolism |
Glycolysis / Gluconeogenesis |
1.22E-02 |
| Carbohydrate metabolism |
Fructose and mannose metabolism |
2.81E-02 |
| Carbohydrate metabolism |
Starch and sucrose metabolism |
1.27E-04 |
| Carbohydrate metabolism |
Galactose metabolism |
1.82E-06 |
| Global and overview maps |
Metabolic pathways |
1.44E-02 |
| Membrane transport |
ABC transporters |
4.67E-12 |
| Metabolism of cofactors and vitamins |
Pantothenate and CoA biosynthesis |
9.35E-03 |
| Metabolism of other amino acids |
Glutathione metabolism |
1.81E-02 |
| Translation |
Aminoacyl-tRNA biosynthesis |
6.15E-04 |
|
| (d) The information of changed pathways in liver. |
| dclass |
Label |
cp-value |
| Amino acid metabolism |
Phenylalanine metabolism |
3.17E-03 |
| Amino acid metabolism |
Alanine, aspartate and glutamate metabolism |
8.63E-04 |
| Amino acid metabolism |
Tyrosine metabolism |
8.51E-03 |
| Amino acid metabolism |
Cysteine and methionine metabolism |
4.68E-03 |
| Amino acid metabolism |
Glycine, serine and threonine metabolism |
3.60E-03 |
| Carbohydrate metabolism |
Citrate cycle (TCA cycle) |
5.96E-04 |
| Carbohydrate metabolism |
Butanoate metabolism |
2.40E-03 |
| Carbohydrate metabolism |
Glyoxylate and dicarboxylate metabolism |
2.91E-03 |
| Carbohydrate metabolism |
Pyruvate metabolism |
1.54E-03 |
| Carbohydrate metabolism |
Ascorbate and aldarate metabolism |
3.31E-03 |
|
aP value was obtained from Mann-Whitney test (model group compared to control group).
bFN is fold change of mean ranks calculated by the Mann-Whitney test(model group compared to control group). “<1” means up-regulated, “>1” means down-regulated.
cP-val is obtained from analysis of MBRole.
dclass were categorized by KEGG. |
| Table 5: The different metabolites and pathways of FLD. |
