Figure 1: Rate of heme synthesis and the levels of heme biosynthetic enzymes are elevated in NSCLC cells. (A) Rate of heme synthesis in cancer (HCC4017) vs. normal (HBEC30KT) cells, in absence or presence of 0.5 mM succinyl acetone (SA). (B) Protein levels of ALAS1 in HBEC30KT and HCC4017 cell lines in absence or presence of 0.5 mM succinyl acetone (SA). (C). Increased levels of ALAS1 enzyme in HCC4017 (HCC) cell line and various human tumor xenograft samples [10].