Groups GPx (nmol of NADPH oxidized/min/mg protein) GR (nmol of NADPH oxidized/min/mg protein) GST (nmol of NADPH oxidized/min/mg protein) CAT (nmol of H2O2consumed/min/mg protein) SOD (nmol (−)-epinephrine protected from oxidation/min/mg protein)
Control 667.49± 51.12 787.30 ± 60.15 1816.12 ±199.60 241.98±12.52 1270.94 ±199.60
Te 453.87* ± 38.62 (-32.01 %) 419.29* ± 43.73 (-46.74 %) 1064.44* ±128.71 (-41.39 %) 177.82* ± 37.94 (-26.51 %) 644.93* ± 52.02 (-49.26 %)
Z1+Te 608.35# ± 65.60 (34.03 %) 629.64#± 94.81 (50.16 %) 1300.22#± 118.08 (22.13 %) 225.07#± 19.14 (26.57 %) 977.11# ± 93.13 (51.50 %)
Z2+Te 634.59#± 49.09 (39.82 %) 715.90##± 54.78 (70.74 %) 1587.9#9 ± 83.97 (49.19 %) 236.39#± 18.21 (32.93 %) 1072.5##± 160.04 (66.29 %)
Te toxicity leads to significant depletion on the activity of antioxidant enzymes (GPx, GR, GST, CAT and SOD) in Te groups as compared to control group (*p<0.05 vs. control group). Administration of zingerone (50 and 100 mg/kg b. wt.) significantly improved the activity of these enzymes in Z1+L and Z2+L groups as compared to Te group (#p<0.05, ##p<0.05 vs. Te group). Values in parentheses show the percentage increase or decrease with respect to their control. Values are expressed as Mean ± SEM of 8 animals.
Table 1: Effect of various doses of zingerone (Z) on the activity of antioxidant enzymes in brain mitochondria of Te toxicated rats.