Figure 1: Schematic overview on the effect of dietary MSE on the KRASdriven oncogenic signaling network associated with cell survival and proliferation, including metabolism in pancreatic cancer. Membrane EGFR and other RTKs play a critical role in the development and progression of many types of cancer. Pro-tumorigenic inflammatory signaling induced in the tumor microenvironment activates KRAS by positive feedback mechanisms via EGFR and RTKs in an autocrine-paracrine manner. Mutated oncogenic KRAS interacts with the PI3K/AKT/mTOR signaling network and transform normal cells, leading to the initiation and progression of pancreatic cancer. Also, oncogenic KRAS signals through the Raf-MEK-ERK pathway and contributes to cancer development and progression. MSE may potentially inhibit these signaling pathways and preventing the formation of early neoplastic lesions and development of pancreatic cancer.