NC NA MA LA
Gender(male/female) 53/52 55/55 54/52 53/52
age 54.46 ± 11.80 54.54 ± 10.55 53.79 ± 13.15 54.45 ± 11.16
duration 0 7.86 ± 6.47 11.35 ± 7.84b 13.22 ± 7.01bc
BMI (kg/m2) 23.52 ± 2.79 25.04 ± 2.23a 25.25 ± 2.25a 25.22 ± 2.88a
SBP (mmHg) 123.20 ± 13.93 127.92 ± 11.01a 135.88 ± 18.56ab 139.45 ± 14.44uhabc
DBP (mmHg) 79.86 ± 9.97 80.72 ± 8.07 80.58 ± 9.69 80.48 ± 10.58
HbA1c (%) 5.22 ± 0.39 8.14 ± 1.98a 8.55 ± 1.85a 9.02 ± 2.20ab
FBG (mmol/L) 5.08 ± 0.45 9.18 ± 3.61a 9.92 ± 3.96a 10.14 ± 3.80ab
FINS (mIU/L) 8.49 ± 2.25 11.32 ± 8.52 13.56 ± 8.77a 15.20 ± 10.52a
TG (mmol/L) 1.28 ± 0.67 2.09 ± 1.58a 2.35 ± 1.51a 2.17 ± 1.09ab
TC (mmol/L) 4.75 ± 0.81 4.53 ± 1.05 4.74 ± 1.03 4.86 ± 1.11
HDL-C (mmol/L) 1.29 ± 0.36 1.06 ± 0.28a 1.08 ± 0.33a 1.04 ± 0.34a
LDL-C (mmol/L) 3.10 ± 0.76 2.87 ± 0.87 2.93 ± 0.89 3.13 ± 1.02
UA (umol/L) 253.78 ± 53.80 289.00 ± 50.99a 333.36 ± 66.33ab 404.19 ± 95.20abc

ACR ( mg/g)

10.3(6.8-13.2) 12.4(7.1-16.7)a 76.8(41.6-109.2)ab 781.6(541.1-930.5)abc
Nampt (ng/mL) 8.56 ± 3.49 19.38 ± 4.10a 29.82 ± 7.19ab 34.54 ± 9.38abc
IL-1β (pg/mL) 76.96 ± 25.97 154.77 ± 31.61a 219.70 ± 55.88ab 273.88 ± 74.77abc
aCompared with NC, P < 0.05; bCompared with NA, P < 0.05; cCompared with MA, P < 0.05
NC = Control group; NA = Normoalbuminuria group; MA = Microalbuminuria group; LA = Large Amount of Albuminuria group; DBP = Diastolic Blood Pressure; SBP = Systolic Blood Pressure; BMI = Body Mass Index; HbA1c = Glycated Hemoglobin; FBG = Fasting Blood Glucose; FINS = Fasting Insulin; TG = Triglycerides; TC = Total Cholesterol; HDL-C = High Density Lipoprotein-Cholesterol; LDL-C = Low Density Lipoprotein-Cholesterol; UA = Uric Acid; ACR = Albumin-to-Creatinine Ratio; Nampt = Nicotinamide phosphoribosyltransferase ; IL-1β = Interleukin-1β.HJ
Table1: Clinical characteristics of the subjects.