Clinical characteristics of the

	NC	NA	MA	LA
Gender(male/female)	53/52	55/55	54/52	53/52
age	54.46 ± 11.80	54.54 ± 10.55	53.79 ± 13.15	54.45 ± 11.16
duration	0	7.86 ± 6.47	11.35 ± 7.84b	13.22 ± 7.01^bc
BMI (kg/m²)	23.52 ± 2.79	25.04 ± 2.23^a	25.25 ± 2.25^a	25.22 ± 2.88^a
SBP (mmHg)	123.20 ± 13.93	127.92 ± 11.01^a	135.88 ± 18.56^ab	139.45 ± 14.44uh^abc
DBP (mmHg)	79.86 ± 9.97	80.72 ± 8.07	80.58 ± 9.69	80.48 ± 10.58
HbA1c (%)	5.22 ± 0.39	8.14 ± 1.98^a	8.55 ± 1.85^a	9.02 ± 2.20ab
FBG (mmol/L)	5.08 ± 0.45	9.18 ± 3.61^a	9.92 ± 3.96^a	10.14 ± 3.80^ab
FINS (mIU/L)	8.49 ± 2.25	11.32 ± 8.52	13.56 ± 8.77^a	15.20 ± 10.52^a
TG (mmol/L)	1.28 ± 0.67	2.09 ± 1.58^a	2.35 ± 1.51^a	2.17 ± 1.09^ab
TC (mmol/L)	4.75 ± 0.81	4.53 ± 1.05	4.74 ± 1.03	4.86 ± 1.11
HDL-C (mmol/L)	1.29 ± 0.36	1.06 ± 0.28^a	1.08 ± 0.33^a	1.04 ± 0.34^a
LDL-C (mmol/L)	3.10 ± 0.76	2.87 ± 0.87	2.93 ± 0.89	3.13 ± 1.02
UA (umol/L)	253.78 ± 53.80	289.00 ± 50.99^a	333.36 ± 66.33^ab	404.19 ± 95.20^abc
ACR ( mg/g)	10.3(6.8-13.2)	12.4(7.1-16.7)^a	76.8(41.6-109.2)^ab	781.6(541.1-930.5)^abc
Nampt (ng/mL)	8.56 ± 3.49	19.38 ± 4.10^a	29.82 ± 7.19^ab	34.54 ± 9.38^abc
IL-1β (pg/mL)	76.96 ± 25.97	154.77 ± 31.61^a	219.70 ± 55.88^ab	273.88 ± 74.77^abc

^aCompared with NC, P < 0.05; ^bCompared with NA, P < 0.05; ^cCompared with MA, P < 0.05
NC = Control group; NA = Normoalbuminuria group; MA = Microalbuminuria group; LA = Large Amount of Albuminuria group; DBP = Diastolic Blood Pressure; SBP = Systolic Blood Pressure; BMI = Body Mass Index; HbA1c = Glycated Hemoglobin; FBG = Fasting Blood Glucose; FINS = Fasting Insulin; TG = Triglycerides; TC = Total Cholesterol; HDL-C = High Density Lipoprotein-Cholesterol; LDL-C = Low Density Lipoprotein-Cholesterol; UA = Uric Acid; ACR = Albumin-to-Creatinine Ratio; Nampt = Nicotinamide phosphoribosyltransferase ; IL-1β = Interleukin-1β.HJ

Table1: Clinical characteristics of the subjects.