Figure 8: MicroRNAs mediate silencing of G6PD in SCC cells. (A). Metabolic reaction catalyzed by G6PD. Grey arrow indicates the decrease in SCC-11 cells, while black arrow indicates the increase in SCC-11M cells. Levels of glucose-6-phosphate (B) and 6-phosphogluconate (C) in SCC-11 cells and SCC-11M cells were analyzed upon indicated treatments (control- CON, cisplatin-CIS). PGLS stands for 6-phosphoglucono-lactonase, (B and C). Assays were performed using three independent experiments in triplicate (*, p<0.05).