Betahistine dihydrochloride

Etilefrine hydrochloride

K’ (S-1)

(M)

K’ (S-1)

(M)

-9.18 x 10-4

-1.67 x 10-4

-1.94 x 10-4

-2.59 x 10-4

-2.97 x 10-4

-2.05 x 10-4

-2.48 x 10-4

-1.98 x 10-4

-1.669 x 10-4

1.19 x 10-6

2.39 x 10-6

4.78 x 10-6

9.56 x 10-6

1.43 x 10-5

1.91 x 10-5

2.39 x 10-5

2.87 x 10-5

3.35 x 10-5

-6.84 x 10-4

-2.99 x 10-4

 -1.78 x 10-4

-1.46 x 10-4

-1.26 x 10-4

-1.78 x 10-4

1.38 x 10-5

2.29 x 10-5

3.22 x 10-5

4.13 x 10-5

5.05 x 10-5

5.97 x 10-5

Table 5: Pseudo-first order rate constants K, corresponding to different drugs concentrations, at constant concentration of NBD-Cl.