Parameter

Healthy

Infected

LSD
(Pr > F)

S

BS

S

BS

C° (mg/ml)

42.35(4.20)^b

41.65(2.12)^b

45.05(3.88)^b

51.60(2.95)^a

4.536(0.001)

A  (mg/ml)

26.22(2.60)^ab

24.70(1.60)^b

25.40(2.27)^ab

27.70(1.35)^a

2.705(0.148)

a  (h^-1)

0.639(0.04)^a

0.591(0.05)^ab

0.560(0.06)^bc

0.512(0.02)^c

0.061(0.003)

t_1/2(a) (h)

1.089(0.08)^c

1.178(0.09)^bc

1.248(0.13)^ab

1.354(0.05)^a

0.125(0.002)

B  (mg/ml)

16.13(1.69)^c

16.95(1.93)^c

19.65(1.75)^b

23.27(1.99)^a

2.469(0.0001)

b  (h^-1)

0.169(0.004)^a

0.149(0.004)^b

0.144(0.008)^b

0.127(0.003)^c

0.007(0.0001)

t_1/2(b) (h)

4.099(0.10)^c

4.669(0.12)^b

4.841(0.25)^b

5.460(0.12)^a

0.215(0.0001)

V_c  (L/kg)

0.467(0.05)^a

0.481(0.02)^a

0.447(0.04)^a

0.389(0.02)^b

0.045(0.002)

V_d(area) (L/kg)

0.875(0.11)^a

0.870(0.10)^a

0.769(0.09)^ab

0.658(0.06)^b

0.124(0.005)

V_d(ss)(L/kg)

0.681(0.09)^a

0.694(0.07)^a

0.628(0.09)^ab

0.545(0.05)^b

0.101(0.026)

Cl_(B)  (L/kg/h)

0.148(0.02)^a

0.129(0.01)^b

0.110(0.008)^c

0.083(0.006)^d

0.014(0.0001)

AUC (µg/ml. h^-1)

0.137(0.01)^c

0.156(0.01)^c

0.183(0.01)^b

0.241(0.02)^a

0.020(0.0001)

AUMC (µg/ml.h^-2)

6..337(0.29)^c

4.838(0.40)^d

7.026(0.22)^b

17.913(0.38)^a

0.443(0.0001)

MRT  (h)

0.047(0.003)^b

0.031(0.001)^d

0.039(0.004)^c

0.075(0.004)^a

0.004(0.0001)