Parameter |
Healthy |
Infected |
LSD
(Pr > F) |
S |
BS |
S |
BS |
C° (mg/ml) |
42.35(4.20)b |
41.65(2.12)b |
45.05(3.88)b |
51.60(2.95)a |
4.536(0.001) |
A (mg/ml) |
26.22(2.60)ab |
24.70(1.60)b |
25.40(2.27)ab |
27.70(1.35)a |
2.705(0.148) |
a (h-1) |
0.639(0.04)a |
0.591(0.05)ab |
0.560(0.06)bc |
0.512(0.02)c |
0.061(0.003) |
t1/2(a) (h) |
1.089(0.08)c |
1.178(0.09)bc |
1.248(0.13)ab |
1.354(0.05)a |
0.125(0.002) |
B (mg/ml) |
16.13(1.69)c |
16.95(1.93)c |
19.65(1.75)b |
23.27(1.99)a |
2.469(0.0001) |
b (h-1) |
0.169(0.004)a |
0.149(0.004)b |
0.144(0.008)b |
0.127(0.003)c |
0.007(0.0001) |
t1/2(b) (h) |
4.099(0.10)c |
4.669(0.12)b |
4.841(0.25)b |
5.460(0.12)a |
0.215(0.0001) |
Vc (L/kg) |
0.467(0.05)a |
0.481(0.02)a |
0.447(0.04)a |
0.389(0.02)b |
0.045(0.002) |
Vd(area) (L/kg) |
0.875(0.11)a |
0.870(0.10)a |
0.769(0.09)ab |
0.658(0.06)b |
0.124(0.005) |
Vd(ss)(L/kg) |
0.681(0.09)a |
0.694(0.07)a |
0.628(0.09)ab |
0.545(0.05)b |
0.101(0.026) |
Cl(B) (L/kg/h) |
0.148(0.02)a |
0.129(0.01)b |
0.110(0.008)c |
0.083(0.006)d |
0.014(0.0001) |
AUC (µg/ml. h-1) |
0.137(0.01)c |
0.156(0.01)c |
0.183(0.01)b |
0.241(0.02)a |
0.020(0.0001) |
AUMC (µg/ml.h-2) |
6..337(0.29)c |
4.838(0.40)d |
7.026(0.22)b |
17.913(0.38)a |
0.443(0.0001) |
MRT (h) |
0.047(0.003)b |
0.031(0.001)d |
0.039(0.004)c |
0.075(0.004)a |
0.004(0.0001) |
(a,b,c,d)Means with the same letter in the same row are not significantly different.
LSD = Least significant difference. |