Parameter

Healthy

Infected

LSD

S

BS

S

BS

t1/2(ab) (h)

4.44(0.09)a

2.37(0.20)b

4.11(0.50)a

2.58(0.09)b

0.372

Cmax (mg/mL)

3.70(0.08)d

6.88(0.23)b

4.06(0.24)c

7.62(0.26)a

0.289

tmax(h)

3.07(0.21)a

1.54(0.10)b

3.01(0.14)a

1.70(0.08)b

0.190

t1/2(el)(h)

12.43(0.90)d

17.23(1.25)b

13.74(0.50)c

22.46(0.96)a

1.262

AUC (µg/ml. h-1)

0.096(0.009)c

0.195(0.02)b

0.108(0.007)c

0.263(0.03)a

0.025

AUCBS/AUCS

-

2.529(0.04)a

-

2.034(0.10)a

0.111

F (AUCi.m/AUCi.v.)

0.704(0.01)c

1.253(0.02)a

0.591(0.04)d

1.132(0.008)b

0.030

(a, b, c, d)Means with the same letter in the same row are not significantly different at
(Pr > F 0.0001). LSD = Least significant difference.
Table 2: Mean (SD) pharmacokinetic parameters of florfenicol in serum (S) and bronchial secretions (BS) after a single intramuscular injection 20 mg/kg b wt in healthy and Pasteurella multocida-infected calves (n = 5).