Parameter |
Healthy |
Infected |
LSD |
S |
BS |
S |
BS |
t1/2(ab) (h) |
4.44(0.09)a |
2.37(0.20)b |
4.11(0.50)a |
2.58(0.09)b |
0.372 |
Cmax (mg/mL) |
3.70(0.08)d |
6.88(0.23)b |
4.06(0.24)c |
7.62(0.26)a |
0.289 |
tmax(h) |
3.07(0.21)a |
1.54(0.10)b |
3.01(0.14)a |
1.70(0.08)b |
0.190 |
t1/2(el)(h) |
12.43(0.90)d |
17.23(1.25)b |
13.74(0.50)c |
22.46(0.96)a |
1.262 |
AUC (µg/ml. h-1) |
0.096(0.009)c |
0.195(0.02)b |
0.108(0.007)c |
0.263(0.03)a |
0.025 |
AUCBS/AUCS |
- |
2.529(0.04)a |
- |
2.034(0.10)a |
0.111 |
F (AUCi.m/AUCi.v.) |
0.704(0.01)c |
1.253(0.02)a |
0.591(0.04)d |
1.132(0.008)b |
0.030 |
(a, b, c, d)Means with the same letter in the same row are not significantly different at
(Pr > F 0.0001). LSD = Least significant difference. |