% Drug release (n=3) TIME ( min) PD (Mean ± SD) PM (Mean ± SD) KN (Mean ± SD) R S R S R S 5 86.93 ± 3.24 85.47 ± 2.91 87.37 ± 2.18 86.53 ± 2.45 86.23 ± 2.45 84.29 ± 2.30 15 93.71 ± 2.45 94.40 ± 3.28 97.25 ± 3.16 96.75 ± 1.84 95.34 ± 3.63 95.26 ± 3.06 30 98.56 ± 3.47 97.86 ± 2.08 99.29 ± 3.14 98.89 ± 3.24 98.57 ± 2.36 98.91 ± 2.13 45 96.92 ± 3.78 96.81 ± 3.03 97.69 ± 2.54 96.45 ± 2.72 95.27 ± 3.40 95.38 ± 3.14 60 95.18 ± 2.96 94.93 ± 3.62 95.26 ± 2.37 9279 ± 3.81 93.14 ± 3.37 92.12 ± 3.35 TIME ( min) SE1 (Mean ± SD) SE2 (Mean ± SD) SE3 (Mean ± SD) R S R S R S 5 85.02 ± 3.02 83.84 ± 2.37 87.25 ± 2.98 85.86 ± 3.12 86.47 ± 2.84 87.73 ± 2.23 15 95.16 ± 2.13 94.95 ± 3.30 97.32 ± 1.23 98.89 ± 2.93 98.16 ± 2.24 98.53 ± 1.97 30 98.78 ± 2.56 98.57 ± 2.76 101.08 ± 1.98 97.94 ± 2.47 100.30 ± 2.82 96.59 ± 3.31 45 97.39 ± 2.91 96.79 ± 3.08 99.42 ± 2.57 95.28 ± 2.34 96.73 ± 3.63 92.76 ± 2.39 60 95.64 ± 2.92 93.86 ± 3.72 95.23 ± 3.12 92.75 ± 3.65 94.37 ± 2.15 90.72 ± 3.42

Table 1: Dissolution data of enantiomers of Amlodipine besylate. PD: Pure Drug; PM: Physical mixture of the drug with HPBC at 1:1 molar ratio. KN: Kneading mixture of the drug with HPBC at 1:1 molar ratio. SE1, SE2 & SE3: Inclusion complexes of the drug with HPBC prepared by solvent evaporation method at 1:1, 1:2 & 1:3 ratio respectively; HPBC: Hydroxy Propyl β – Cyclodextrin; SD: Standard deviation.