Compound Solvency Cogent EE Cellulose Carbonate (% IPA required for elution) Traditional Cellulose Carbonate (% IPA required for elution) TSO Readily dissolves in 100% hexane 0.5 10 Propranolol Readily dissolves in 96% hexane/4% IPA 4 20 Pindolol Insoluble in 80% hexane/20% IPA 35 20

Table 2: Relationship Between Chiral Target Solvency and LC Eluent Choice.