Panadol night® tablets claimed to contain 25mg DPH and 500 mg PAR/tablet (Batch No 117928) |
Technique |
component |
Taken (μg mL-1) |
Found % ± SD |
First derivative spectrophotometric method (D1) |
PAR |
4 |
98.50
±
0.76 |
First derivative of ratio spectra specrophotometric method (DD1) |
DPH |
8*(7.5pure + 0.5 dosage form) |
102.00
±
0.72 |
Multivariate method |
PAR |
PLS |
4 |
99.25
±
0.39 |
100.99
±
1.47 |
PCR |
4 |
98.35
±
0.85 |
99.37
±
1.40 |
DPG |
PLS |
7* |
101.40
±
0. 31 |
99.58
±
1.63 |
PCR |
7* |
98.20
±
0.25 |
99.70
±
1.35 |
Densitometric method |
PAR |
0.4 |
99.00
±
0.25 |
100.00
±
1.31 |
DPH |
5 |
101.60
±
1.70 |
101.70
±
1.62 |
* The ratio present in Panadol night® tablets prepared by spiking technique [17], where 7μg/mL of DPH is (6.5 μg/mL of pure drug + 0.5 μg/mL of dosage form) |