Pharmacological class |
Drug* |
Impaired
metabolism |
CYP |
Antihypertensives |
nifedipine, felodipine, diltiazem
propranolol
irbesartan
verapamil |
yes
no
no
yes |
3A4/3A5
2D6
2C9
several |
Antiarrhythmics |
amiodarone, lidocaine |
yes |
3A4/3A5 |
Anxiolytics/hypnotics
|
triazolam, zolpidem
diazepam
midazolam |
yes
no
no |
3A4/3A5
3A4/3A5
3A4 |
Antidepressants
|
amitriptyline
sertraline
fluoxetine, nortriptyline, venlafaxine
citalopram
imipramine |
yes
no
no
no
yes |
3A4/3A5
3A4/3A5
2D6
2C9
2C19 |
Anticonvulsants |
carbamazepine
phenytoin |
yes
no |
3A4/3A5
2C9 |
Antipsychotics |
risperidone |
no |
2D6 |
Analgesics (opioids) |
fentanyl
alfentanil |
yes
no |
3A4/3A5
3A4/3A5 |
NSAIDs |
paracetamol
naproxen
celecoxib, diclofenac
ibuprofen |
no
yes
no
no |
3A4/3A5
2C9
2C9
several |
Antibiotics |
cyclosporine |
yes |
3A4/3A5 |
Anticoagulants |
warfarin |
yes |
2C9 |
* When the drug belongs to two or more pharmacological classes, it is presented
in only one class
CYP – cytochrome P450; NSAIDs – Non-steroidal anti-inflammatory drugs |