Pharmacological class Drug

Impaired metabolism

Type of reaction
Analgesics (opioids) morphine

yes

glucuronidation
NSAIDs salicylic acid
paracetamol

no
no

glucuronidation
glutation conjugation
Antibiotics isoniazid

no

acetylation
NSAIDs - Non-steroidal anti-inflammatory drugs
Table 4: Phase II drug biotransformation characteristics in the elderly (modified from Turnheim).