Moxifloxacin- Limit of detection (LOD) & Limit of Quantification (LOQ)

S.No.

Injection No.

Slope

Y-Intercept

R2

1

Inj-1

23059.4

27156.504

0.999

2

Inj-2

23184.9

25399.4381

0.999

3

Inj-3

23070.2

31121.98583

0.998

Average

23104.8333

27892.6426

0.9987

STDEV

69.550

2931.435

0.001

LOD=3.3 x σ/S

LOD

0.4

ppm

 

 

LOQ=10 x σ/S

σ = Standard deviation of y-intercepts of regression line

S= slope of the linearity curve

LOQ

1.3

ppm

 

 

Acceptance Criteria: LOD & LOQ values shall be less than the minimum linearity concentration

Table 6: