Parameters DDRD HDDR
MEH DF MET
MEH DF MET
Dimetrol® tablets
(B.No.909537)
100.39
± 1.285
99.24
±1.883
98.88
± 0.775
101.08
±1.534
101.16
±0.653
98.99
± 0.539
Standard addition a 99.46
±0.962
98.94
±1.859
99.79
± 1.206
98.66
±1.781
102.61
±1.259
99.50
± 1.330
Degree of freedom
F-test
10
(5.050) b
1.683
10
(5.050) b
4.937
10
(5.050) b
1.014
9
(5.192) b
2.432
9
(6.256) b
0.603
10
(5.050) b
4.205
Degree of freedom
Student's –t test
10
(2.228) b
0.819
10
(2.228) b
1.954
10
(2.228) b
2.174
9
(2.262) b
1.522
9
(2.262) b
1.522
10
(2.228) b
0.439
a: Average of 3 determinations.
b: The values in the parenthesis are the corresponding theoretical values at p= 0.05.
Table 4: Application of the proposed spectrophotometric methods for the determination of the studied drugs in tablets and statistical comparison with the manufacturer
RP-HPLC method [39].