Formula code
PCL
(g)
Eudragit RS or EC
(g)
Encapsulation efficiency
(%) ± SD
Production yield
(%) ± SD
Mean diameter
(mm) ±SD
Polydi-spersity
Viscosities of dispersion medium
(mPa s)
F1
1.0
0.00
90.72 ± 1.78
92.34 ± 3.21
225 ± 1.82
0.436
14.0
F2
0.2
0.8
92.87 ± 1.09
90.38 ± 4.10
318 ± 1.72
0.094
17.6
F3
0.5
0.5
89.32 ± 2.72
88.92 ± 2.81
312 ± 2.80
0.340
15.8
F4
0.7
0.3
92.36 ± 3.84
94.31± 4.82
305 ± 1.35
0.610
15.2
F5
0.8
0.2
94.59 ± 2.63
89.43± 5.71
280 ± 2.09
0.316
14.7
F6
0.2
0.8
91.67 ± 3.98
88.87 ± 5.44
375 ± 1.93
0.071
20.0
F7
0.5
0.5
93.75 ± 4.65
89.32 ± 3.98
355 ± 3.85
0.078
18.3
F8
0.7
0.3
90.27 ± 4.44
91.38 ± 2.95
330 ± 2.84
0.056
16.3
F9
0.8
0.2
94.28 ± 1.62
96.32 ± 3.76
270 ± 1.65
0.115
15.4
F2-F5 microparticles composed of PCL/RS blend
F6-F9 microparticles composed of PCL/EC blend
F1-F9 GLZ content is 33.3% (1:2, GLZ: polymer)
Table 1:
Quantitative analysis of the GLZ-loaded Polycaprolactone microparticles (n=3).