Pharmacokinetic parameter F 2 F 7 GLZ solution Dunn’s multiple comparison Test
P value
Cmax (ng/ml) 1706.5 ± 165.3 1890. 1± 150.2 1875.6 ± 55.3 P> 0.05 F2 & F7
P> 0.05 F7& Solution
P > 0.05 F2 & solution
Tmax(h) 8.02 ±1.02 6.48± 0.86 3.24± 0.58 P > 0.05 F2 & solution
P > 0.01 F7& solution
P> 0.05 F2& F7
AUC0-24 (ng/ml/h) 21741.3± 696.6 20464.5± 1326.7 8214.7 ± 403.1 P> 0.05 F2 & F7
P> 0.05, F2, F7 & Solution
AUC0-∞ (ng/ml/h) 23135.2± 1819.2 21314.2± 1349.1 11393.6 ± 452.6 P> 0.001 F2, F7 & Solution
MRT (h) 11.21 ±1.85 12.83± 1.32 9.85± 2.43 P > 0.05 F2, F7 & solution
Lag time (h) 0.86 0.42 0.00  
Table 2: Mean pharmacokinetic parameters of gliclazide after oral administration of Formula F7, F2 microparticles and GLZ solution to six rabbits (n=6).