Formula code Zero order First order Higuchi Korsmeyer-Peppas % burst release after 1 hour ± SD T50%
(h)
r k0 r k1 r kH r n  
F1 0.920 11.795 -0.890 -0.302 0.944 39.155 0.989 0.491 40 ± 1.43 2.5
F2 0.994 9.721 -0.991 -0.083 0.983 29.925 0.993 0.803 17 ± 2.76 4.5
F3 0.982 10.385 -0.984 -0.111 0.992 32.616 0.990 0.593 25 ± 2.80 3.5
F4 0.972 10.440 -0.983 -0.130 0.994 33.238 0.982 0.508 31 ± 3.62 3.0
F5 0.969 10.748 -0.904 -0.188 0.993 34.179 0.979 0.455 37 ± 1.78 3.0
F6 0.988 6.405 -0.984 -0.040 0.964 19.377 0.989 0.673 12 ± 3.82 3.5
F7 0.988 11.368 -0.986 -0.118 0.982 35.116 0.997 0.797 18 ± 2.98 7.0
F8 0.977 10.841 -0.984 -0.131 0.994 34.299 0.996 0.582 29 ± 3.89 3.0
F9 0.962 11.769 -0.934 -0.200 0.992 37.796 0.985 0.502 36 ± 4.20 2.5
Pure GLZ 0.989 13.439 -0.947 -0.165 0.944 39.858 0.982 1.052  - 4.0
Table 3: Correlation coefficient and T50%, calculated from the release data of GLZ-loaded Polycaprolactone microparticles after fitting the whole release profile of GLZ from various microparticles into different mathematical models (n=3).