Compounds 

ID50 with 0.5% FBS

ID50 with 2% FBS

LD50

ID50<<LD50

 

 

 

Roscovitine

1.23

7.50

 -

Y-27632

4.40

6.06

 -

Tyrphostin AG879

5.91

8.19

 -

Ethacrynic acid

2.64

10.0

 -

Metrifudil

6.09

10.0

 -

N6-(2-Amino-phenyl)ethyladenosine

9.65

10.0

 -

N6-Cyclohexyladenosine

10.0

10.0

 -

Nitrendipine

9.65

10.0

 -

Wortmannin

10.0

10.0

 -

ID50<LD50

 

 

 

H-7

5.78

9.65

>10.0

Sodium pravastatin

10.0

10.0

>10.0

Simvastatin

2.07

4.04

>10.0

BQ-123

3.56

8.93

>10.0

BQ-788

3.05

7.88

>10.0

LY294002

3.98

10.0

>10.0

CGS15943

2.28

3.00

>10.0

15-Deoxy prostaglandin J2

3.21

7.33

>10.0

ID50>LD50

 

 

 

CP55940

2.51

6.80

7.84

BIM I

2.57

3.40

7.21

Chelerythrine chloride

0.49

0.44

0.52

Ouabain

0.06

0.36

0.07

Okadaic acid

0.08

0.07

0.05

 

 

 

(x10-6 M)

- : not determined
Table 1: ID50 and LD50 Values for Various Inhibitors of Collagen Gel Contraction by pMA Cells.