Batches Weight variation Hardness
Kg/cm2
%friability Wetting time Water absorption ratio In-vitro disintegration time % drug release (Q5min)
A1 Passes   3.6   0.40 85±2 62.23±0.046 77 ±1.52 100.90±1.85
A2 Passes   3.5   0.55 63±2 102.84±0.752 50±2 101.29±1.46
A3 Passes   3.4   0.46 79±1.732 77.60±1.105 70±1.73 100.40±0.74
A4 Passes   3.4   0.35 85±1.527 68.80±0.732 72±2 100.30±1.84
A5 Passes   3.5   0.31 73±0.577 98.32±1.037 64±2 99.35±0.70
A6 Passes   3.5   0.36 109±2 63.40±1.173 97±1.52 100.63±0.65
A7 Passes   4.2   0.25 99±1.732 60.78±0.751 89±2 90.82±3.03
A8 Passes   4.0   0.25 84±2 63.83±0.594 74±1.52 92.89±1.19
A9 Passes   4.2   0.35 106±1.527 57.14±0.970 97±1.15 88.90±2.4
Control Passes   3.8   0.40   143±0.711 51.75±0.242 138±0.33 72.32±2.19
Table 8: Evaluation of post compression parameters of optimized batches.