Compound Relative TMAE Reference Rsv (10 mM) 1.399 [19] 2DG (4 mM) 4.115 [19] 2DG (8 mM) 2.804 [19] b-thujaplicin (10 mM) 2.078 [22] Rapamycin (1 mM) 1.256      unpublished Relative TME = TME(CR mimetics)/TMEcontrol Here, each constant was set as k1=k2=k3=…=kN=1.

Table 1: TME value in HeLa S3 cells.