Parameters Amantadine Memantine
Linearity ng mL-1 23.80 - 2380.0 23.80 - 1190.0
LOQ ng mL-1 23.80 23.80
Regression equation    
 Slope (b)a 0.003 3.0 x 10-3
 SE of slope 2.79 x 10-5 9.6 x 10-5
Intercept (a)a 0.178 0.128
 SE of intercept 0.03 0.05
Correlation coefficient (r)    
 SE of estimation 0.9998 0.998
Recovery 0.060 0.097
 Meanb± RSD%   98.83 ± 3.03   99.61 ± 3.20
aRegression equation, A = a + bc, where A is the peak intensity ratio for m/z = 152.0 /180.0 for Am, and A is the peak intensity ratio for m/z = 180.0/152.0 for mem, C is the concentration in ng mL-1.
bn = 6.
Table 1: Validation report of the proposed TOF ES-MS assay for determination amantadine and memantine in drug substances.