Drug substances
Conc. ng mL
-1
Precision
a
RSD%
Accuracy
a
RE%
Intra
Inter
Intra
Inter
Amantadine
59.5
1.89
2.00
-2.67
1.59
1190.0
1.07
1.59
-1.58
-2.19
2380.0
1.94
1.98
-2.11
2.00
Memantine
23.8
1.03
1.96
1.14
1.97
595.0
1.60
2.00
1.55
2.00
1190.0
1.15
1.90
1.90
1.77
a
n = 3
Table 2:
Intra and inter-day precision and accuracy of the proposed TOF ES-MS method for analysis of amantadine and memantine in drug substances.
