Losartan potassium

Principle peak

Degradation peak

Sum of peak

Principle peak %

Degradation peak %

3 days (25°C)

4801.31

483.62

5284.93

90.85

9.151

3 days (70°C)

493.96

3597.9

4091.86

12.07

87.93

7 days (25°C)

3028.6

538.87

3567.47

84.89

15.11

7 days (70°C)

455.12

3228.05

3683.17

12.36

87.64

14 days (25°C)

2765.89

1180

3945.89

70.1

29.9

14 days (70°C)

453.8

3071

3524.8

12.87

87.13

Valsartan

Principle peak

Degradation peak

Sum of peak

Principle peak %

Degradation peak %

3 days (25°C)

3896.52

45.48

3942

98.85

1.154

3 days (70°C)

2282.36

1427.87

3710.23

61.52

38.48

7 days (25°C)

4954.97

95.73

5050.7

98.1

1.895

7 days (70°C)

1938.32

2943.72

4882.04

39.7

60.3

14 days (25°C)

5110.7

150

5260.7

97.15

2.851

14 days (70°C)

1176.08

3045.26

4221.34

27.86

72.14

Irbesartan

Principle peak

Degradation peak

Sum of peak

Principle peak %

Degradation peak %

3 days (25°C)

6521.5

2749.24

9270.74

70.34

29.66

3 days (70°C)

283.69

8453.58

8737.27

3.247

96.75

7 days (25°C)

5001.21

4289.9

9291.11

53.83

46.17

7 days (70°C)

314.76

9286.84

9601.6

3.278

96.72

14 days (25°C)

2751.72

6374.8

9126.52

30.15

69.85

14 days (70°C)

169.15

9116.94

9286.09

1.821

98.18

Table 9: Percentages of degradation by normalization method for Losartan potassium, Valsartan and Irbesartan respectively.