SAM         FLU           HPLC D1 DD1   iso HPLC D1 DD1   Iso       334 337.5 343     225 231.5 237.5 X- 100.47 100.48 100.132 100.62 100.73 100.81 101.04 100.65 100.46 100.48 ±SD 0.788 1.182 0.924 0.957 1.298 0.498 1.311 0.971 1.543 1.330 %RSD 0.784 1.176 0.923 0.951 1.289 0.494 1.298 0.965 1.536 1.324 N 5 5 5 5 5 5 5 5 5 5

Table 4: Determination of SAM and Fluticasone propionate in laboratory prepared mixtures by the proposed methods.