Method |
Amount, µg.mL-1 |
Carvedilol (CARV) |
Hydrochlorothiazide (HCT) |
Taken |
Added |
Found ± RSDa |
Recovery ± RSD (%) |
Found ± RSDa |
Recovery ± RSD (%) |
3D |
|
245.9 nm |
230.2 nm |
10.0 |
5.0 |
4.94 ± 0.05 |
98.80 ± 1.01 |
4.99 ± 0.04 |
99.80 ± 0.80 |
10.0 |
7.5 |
7.60 ± 0.6 |
101.33 ± 0.79 |
7.48 ± 0.03 |
99.73 ± 0.40 |
10.0 |
10.0 |
9.97 ± 0.09 |
99.70 ± 0.90 |
10.05 ± 0.06 |
100.50 ± 0.60 |
Mean ± RSD(%) |
|
99.94 ± 0.90 |
|
100.01 ± 0.60 |
4D |
|
247.4 nm |
226.9 nm |
10.0 |
5.0 |
5.02 ± 0.04 |
100.40 ± 0.80 |
4.97 ± 0.05 |
99.40 ± 1.101 |
10.0 |
7.5 |
7.47 ± 0.05 |
99.60 ± 0.67 |
7.55 ± 0.04 |
100.66 ± 0.53 |
10.0 |
10.0 |
10.03 ± 0.09 |
100.30 ± 0.90 |
9.95 ± 0.07 |
99.50 ± 0.70 |
Mean ± RSD(%) |
|
100.10 ± 0.79 |
|
99.85 ± 0.75 |
1DD |
|
236.1 nm |
261.1 nm |
10.0 |
5.0 |
4.98 ± 0.03 |
99.60 ± 0.60 |
5.02 ± 0.02 |
100.40 ± 0.40 |
10.0 |
7.5 |
7.51 ± 0.04 |
100.13 ± 0.53 |
7.49 ± 0.05 |
99.87 ± 0.67 |
10.0 |
10.0 |
9.99 ± 0.07 |
99.90 ± 0.70 |
10.02 ± 0.08 |
100.20 ± 0.80 |
Mean ± RSD(%) |
|
99.88 ± 0.61 |
|
100.16 ± 0.62 |
a Mean of five independent analyses |