Analyte Principle/Detection LOD Range Sampling Ref
Indomethacin Reagent-free method based on photo-induced flurimetric detection (287/378nm) 1.2  µmol L-1 4.1-90 µmol L-1 20 [11]
Captopril On-line derivatization with methyl and butyl propiolate esters (285nm) 0.2  µmol L-1 10-220  µmol L-1 40 [12]
Gemfibrozil On-line dilution based on zone-sampling by coupling of SI to fast HPLC 2.3  mg L-1 30-750 mg L-1 60 [13]
Mexiletine On-line derivatization by o-phthalaldehyde in the presence of sulfite followed by fluorimetric detection (350/446) 3.4  mg L-1 10-300  mg L-1 25 [14]
Propranolol Native fluorescence of propranol HCl in Krebs-Ringer Buffer (ex: 210nm) 0.02  mg L-1 0.2-80  mg L-1  60 [15]
Aminocaproic acid On-line derivatization by o-phthalaldehyde in the presence of N-acetylcysteine followed by fluorimetric detection (350/450 nm) 0.25  µmol L-1 0-60  µmol L-1 40-50 [16]
Prazosin HCl Native fluorescence of prazosin HCl (244/389 nm) 0.007  mg L-1 0.02-2.43  mg L-1 70 [17]
Ascorbic acid Seperation by SI coupled to solid phase extraction 10-100  mg L-1 1.0  mg L-1 26 [18]
Rutin trihydrate Detection at 262 nm. 2-20  mg L-1 1.5  mg L-1    
Ergotamine tartrate Native fluorescence of Ergotamine (236/390 nm) 0.01  mg L-1 0.03-0.61  mg L-1 120 [19]
Acetylsalicylic acid Potentiometric detection by ion-selective electrode 0.05  mmol  L-1 0.05-10 mmol  L-1 20 [20]
Table 1: Applications of SI to drug dissolution studies.