Sample Aqueous solubility (µg/ml) Mole fraction ΔG298sol (kJ mol−1) ΔH298sol (kJ mol−1) T ΔS298 sol (kJ mol−1) ΔS298sol (J mol−1 K−1) CXB 6.4 0.302´10−6 37.18 47.1 ± 1.3 -9.92 -33.2886 CXB-FA 73.4 3.464´10−6 31.15 48.2 ± 1.4 -17.05 -57.2148 CXB-HA 61.6 2.907´10−6 31.58 39.1 ± 0.1 -7.52 -25.2349 1: 1 CXB-β CD 43.8 2.067´10−6 32.42 38.3 ± 0.5 -5.88 -19.7315 CXB-HP- β- CD 44.9 2.11´10−6 32.37 39.6 ± 0.2 -7.23 -24.2617 CXB- Caff 32.7 1.543´10−6 33.15 49.4 ± 1.1 -16.25 -54.5302

Table 3: Saturation solubility of complexes at pH 7 (aqueous). Experiment was carried out at room temperature (298 K) and in a triplicate mode.