Figure 2: Typical chromatograms for the determination of lappaconitine and tetrahydropalmatine in samples: (A) chromatogram of a blank plasma sample; (B) chromatogram of a plasma sample spiked with lappaconitine hydrobromide transfersomes and internal standard (I.S.); (C) chromatogram of the plasma sample collected between 12 h and 24 h after transdermal administration of 10 mg/ml of hydrobromide transfersomes.