Concentration added to plasma (ng/ml) Intra-day (n=6) Inter-day (n=4)
Mean measured concentration (ng/ml) Accuracy (%) RSD (%) Mean measured concentration (ng/ml) Accuracy (%) RSD (%)
10 8.88 ± 0.72 88.8 8.11 8.95 ± 0.61 89.5 6.82
400 372.5 ± 8.46 93.1 2.27 377.6 ± 11.67 94.4 3.09
1000 875.5 ± 5.78 87.5 0.66 901.0 ± 6.33 90.1 0.70
Table 1: Intra-day and inter-day precision and accuracy of LC/MS determination of lappaconitine in rats plasma.