Concentration added to plasma (ng/ml) Room temperature (8 h) Four freeze-thaw circles
Mean measured concentration (ng/ml) Accuracy (%) RSD (%) Mean measured concentration (ng/ml) Accuracy (%) RSD (%)
10 8.75 ± 0.73 87.5 8.34 8.42 ± 0.41 84.2 4.87
400 369.4 ± 11.32 92.4 3.06 355.6 ± 9.24 88.9 2.60
1000 934.6 ± 18.91 93.4 2.02 978.7 ± 15.34 97.9 1.57
Table 3: Stability of lappaconitine in rats plasma (n=6).