parameters     Statistical moment parameters    
t1/2α h 6.013 AUC(0-t) ug/L*h 65.292
t1/2β h 10.108 AUC(0-∞) ug/L*h 65.531
V1/F L/kg 209.773 AUMC(0-t)   2527.314
CL/F L/h/kg 182.692 AUMC(0-∞)   2552.735
AUC(0-t) ug/L*h 53.886 MRT(0-t) h 38.708
AUC(0-∞) ug/L*h 54.737 MRT(0-∞) h 38.955
K10 1/h 0.871 VRT(0-t) h^2 254.471
K12 1/h 0.774 VRT(0-∞) h^2 270.65
K21 1/h 0.086 Zeta 1/h 0.095
Ka 1/h 0.28 Zeta 123
t1/2Ka h 2.477 Cz ug/L 0.023
Tlag h 0 t1/2z h 7.32
      Tmax h 24
      Vz/F L/kg 1611.844
      CLz/F L/h/kg 152.601
      Cmax ug/L 1.51673914
Table 4: Pharmacokinetic parameters for lappaconitine hydrobromide transfersomes after transdermal administration of 10 mg/ml of rats.