% of non-ionized forms
Isoflavone MW pKaa logPb logD6.0b logD7.4b pH 6.0 b pH 7.4 b
Genistein 270 6.51 3.08 2.98 2.22 80.1 13.4
DHG 272 7.52 2.73 2.72 2.61 98.7 75.6
Daidzein 254 7.01 2.73 2.61 1.77 75.0 10.4
DHD 256 7.71 2.38 2.37 2.23 98.3 70.2
DHG, dihydrogenistein; DHD, dihydrodaidzein; MW, molecular weight
aSciFinder Scholar.
b Marvin Sketch (http://www.chemaxon.com/marvin).
Table 1: Physicochemical properties of test compounds. Molecular weights, estimated pKa, logP and logD and presence of non-ionized forms.